In this tutorial you can see how easy it is to use resources using Visual Basic.NET.
Check out the website to download source files and find other tutorials and how to.
http://mkasoft.com/index.php/how-to/51-how-to-use-resources-vb-net

Thanks to: AntonisAsc who showed me an even easier way to do it:
PictureBox1.image = My.Resources.Koala
as for using the resource file try using:
PictureBox1.image = My.Resources.RFILE.wxyz